Material for Predicting tissue specific transcription factor binding sites
نویسندگان
چکیده
Our k-mer based PBM model (Figure 1a in main text) is motivated by the biophysics of TF binding to the probes in PBM experiments. Following Zhao et al. [1], we denote by Yi the experimentally measured intensity of the i-Th. probe on the PBM array. We denote by F (i) the (unobserved) binding probability of the TF to this probe. While these two quantities are related, due to experiential errors and scaling they are not identical. We thus assume a simple linear model for the mapping between the two:
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تاریخ انتشار 2013